Generic Name: Sufentanil Citrate
Class: Opiate Agonists
VA Class: CN101
Chemical Name: N – [4 - (Methoxymethyl) - 1 - [2 - (2 - thieyl)ethyl] – 4 – piperidinyl] – N – phenylpropanamide2 – hydroxy – 1,2,3 – propanetricarboxylate (1:1)
Molecular Formula: C22H30N2O2S•O6H8O7
CAS Number: 60561-17-3
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Opiate agonist; synthetic phenylpiperidine derivative.1 3 4 5
Uses for Sufenta
As the analgesic component in the maintenance of balanced anesthesia (e.g., IV hypnotic and/or inhalation anesthetic, analgesic, skeletal muscle relaxant).1 17 34 36 41 46
As the primary anesthetic agent for induction and maintenance of general anesthesia when used in conjunction with 100% oxygen and a skeletal muscle relaxant (e.g., pancuronium bromide, succinylcholine chloride).1 10 11 12 13 15 16 18 35 37 38 39 43 44 45
Particularly useful when postoperative ventilation is anticipated and in providing favorable myocardial and cerebral oxygen balance.1 11 19 40 41 46
Cardiovascular parameters generally are more stable intraoperatively with use of sufentanil compared with inhalation agents.36 41 Incidence of postoperative hypertension and requirements for vasoactive agents or postoperative analgesics generally are decreased following use of moderate or high doses of sufentanil as compared with use of inhalation agents.1 36 38 41
Obstetric analgesia during labor and vaginal delivery.1 88
Sufenta Dosage and Administration
- Selection of preanesthetic medication(s) should be based on the individual needs of the patient.1
Administer by IV injection, intermittent or continuous IV infusion, or epidural injection.1 4 7 8 10 11 12 13 19
For solution and drug compatibility information, see Compatibility under Stability.
Administration of small volumes may require use of a tuberculin syringe or equivalent.1
Rate of Administration
Administer by slow injection or intermittent or continuous infusion; individualize rate based on patient’s needs.1
Concomitant Administration of a Neuromuscular Blocking Agent
Risk of muscular rigidity (particularly of the truncal muscles) is related to the dose and rate of the infusion; however, administration of a neuromuscular blocking agent prior to sufentanil therapy can reduce the risk.1
The neuromuscular blocking agent used should be compatible with the patient’s condition, taking into account the hemodynamic effects of the drug, the cardiovascular status of the patient, existing drug therapy (e.g., preoperative use of β-adrenergic blocking agents), and the degree of skeletal muscle relaxation required.1
Administration of a Neuromuscular Blocking Agent with Sufentanil1
| Sufentanil Dosage
|| Neuromuscular Blocking Agent Dosage
| <8 mcg/kg
|| Administer up to 25% of the full paralyzing dose just prior to sufentanil1
| >8 mcg/kg (titrated by slow IV infusion)
|| Administer a full paralyzing dose following loss of consciousness (e.g., loss of eyelash reflex, loss of response to voice command)1 61
| >8 mcg/kg (rapidly administered anesthetic doses)
|| Administer a full paralyzing dose simultaneously with sufentanil1 or immediately after loss of consciousness61
For drug compatibility information, see Compatibility under Stability.
Specialized techniques are required for epidural administration; administration should be performed only by qualified individuals familiar with the techniques of administration, dosages, and special patient management problems associated with epidural administration.1
Available as sufentanil citrate; dosage expressed in terms of sufentanil.1
Adjust dosage carefully according to body weight, individual requirements and response, physical status and underlying pathologic condition, premedication or concomitant medication(s), the anesthetic(s) being used, and the nature and duration of the surgery.1
Administer additional doses when patient movement and/or changes in vital signs indicate surgical stress or lightening of analgesia, and adjust according to individual requirements, response, and the anticipated remaining duration of the surgical procedure.1
General Anesthesia (as sole anesthetic agent) for Cardiovascular Surgery
IV Children <12 years of age: Initially, 10–25 mcg/kg in conjunction with 100% oxygen and a skeletal muscle relaxant.1 8 61 Additional doses of up to 25–50 mcg each (or, alternatively, 1–2 mcg/kg each)61 may be given as needed based on response to the initial dose and as determined by changes in vital signs that indicate surgical stress or lightening of anesthesia.1
Neonates: Reduce dosage, especially in those with cardiovascular disease, according to the decrease in clearance.89 (See Pediatric Use under Cautions.)
Analgesic Component of General Anesthesia
IV Minor surgical procedures (expected duration of anesthesia is 1–2 hours): Total dosage of 1–2 mcg/kg in conjunction with nitrous oxide and oxygen; ≥75% of the total dosage may be given by slow injection or infusion prior to intubation.1 88 May administer supplemental doses of 10–25 mcg or administer intermittent or continuous maintenance infusions as necessary when movement and/or changes in vital signs indicate surgical stress or lightening of anesthesia; adjust maintenance infusion rate so that total dosage does not exceed 1 mcg/kg per hour of expected surgical time.1 88
Major surgical procedures (expected duration of anesthesia is 2–8 hours): Total dosage of 2–8 mcg/kg in conjunction with nitrous oxide and oxygen; ≤75% of the total dosage may be given by slow injection or infusion prior to intubation.1 88 May administer supplemental doses of 10–50 mcg or administer intermittent or continuous maintenance infusions as necessary when movement and/or changes in vital signs indicate surgical stress or lightening of anesthesia; adjust maintenance infusion rate so that total dosage does not exceed 1 mcg/kg per hour of expected surgical time.1 88
General Anesthesia (as sole anesthetic agent)
IV Total dosage of 8–30 mcg/kg (by slow injection, infusion, or injection followed by infusion) in conjunction with oxygen and a skeletal muscle relaxant.1 88 Depending on the initial dose, may administer additional incremental doses of 0.5–10 mcg/kg by slow injection in anticipation of surgical stress (e.g., incision, sternotomy, cardiopulmonary bypass).1 88 Alternatively, may administer intermittent or continuous maintenance infusions as necessary as determined by changes in vital signs that indicate surgical stress and lightening of anesthesia; adjust maintenance infusion rate so that total dosage for the procedure does not exceed 30 mcg/kg.1 88
Epidural 10–15 mcg (in combination with 10 mL of bupivacaine 0.125% with or without epinephrine).1 88 Doses may be repeated twice (for a total of 3 doses) at ≥1-hour intervals until delivery.1 88
Analgesic Component of General Anesthesia
IV Minor or major surgical procedures: Total dose of ≤1 mcg/kg per hour of expected surgical time.1
General Anesthesia (as sole anesthetic agent)
IV Total dose for procedure: ≤ 30 mcg/kg.1
Adjust dosage carefully; elimination of the drug may be decreased.1 60
Adjust dosage carefully; elimination of the drug may be decreased.1 60
Geriatric and Debilitated Patients
Reduce initial dosage;1 adjust additional doses according to the initial response and desired effect.1 61
Base dosage on an estimate of ideal (lean) body weight if body weight exceeds ideal weight by >20%.1
Cautions for Sufenta
- Known hypersensitivity to sufentanil or intolerance to other opiate agonists.1
Shares the toxic potentials of the opiate agonists; observe the usual precautions of opiate agonist therapy.1 4
Respiratory function can be severely compromised.1
Consider the possibility of a recurrence of respiratory depression during recovery.4 A secondary rise in plasma concentrations may occur during the recovery period as blood perfusion to peripheral tissues increases and drug redistribution occurs.4
Administration of an opiate antagonist (e.g., naloxone) can reverse respiratory depression.1 The duration of respiratory depression produced by sufentanil may be longer than the duration of the opiate antagonist; therefore, continue appropriate patient monitoring following apparent initial reversal.1
Should be administered only by individuals experienced in the use of parenteral anesthetics and in the maintenance of an adequate airway and respiratory support.1
Opiate antagonist (e.g., naloxone) and facilities for intubation, administration of oxygen, and assisted or controlled respiration should be immediately available.1
Monitor vital signs routinely during administration; facilities for postoperative monitoring and assisted or controlled respiration should be available following administration of anesthetic doses of the drug (i.e., ≥8 mcg/kg).1
Possible skeletal muscle rigidity (e.g., of the truncal muscles); onset may be more rapid than with fentanyl.1 Administration of a neuromuscular blocking agent may be necessary.1 (See Concomitant Administration of a Neuromuscular Blocking Agent under Dosage and Administration.)
Caution in patients with head injuries; sufentanil may obscure the clinical course.1
Caution in patients with pulmonary disease, decreased respiratory reserve, or potentially compromised respiratory function.1 Further decreases in respiratory function and increases in airway resistance may occur.1
Generally produces few cardiovascular effects.4 8 13 17 39 Possible hypotension1 8 10 34 36 39 40 or hypertension.1 8 10 18 35 37 38 40 41 42 Bradycardia occurs infrequently during anesthesia and may be corrected by administration of atropine.1
Used epidurally for analgesia during labor and delivery.1 88 Not recommended for IV use during labor and delivery; avoid epidural dosages in excess of the recommended dosage.1
Not known whether sufentanil is distributed into milk.1 Caution if used in nursing women.1
Safety and efficacy documented in a limited number of children ≥1 day of age undergoing cardiovascular surgery.1 8 89
Use with caution in neonates because decreased clearance may result in increased blood concentrations of the drug.89 Clearance in healthy neonates is approximately one-half that reported in adults and children; may be further reduced by up to one-third in neonates with cardiovascular disease.89
Consider dosage reduction.1 61 (See Geriatric and Debilitated Patients under Dosage and Administration.)
Use with caution, since the drug undergoes metabolism in the liver.1
Use with caution, since the drug and its metabolites are eliminated mainly by the kidneys.1
Common Adverse Effects
Respiratory depression,1 38 skeletal muscle rigidity (e.g., truncal muscles, neck, extremities).1 4 13 38
Interactions for Sufenta
| β-Adrenergic blocking agents
|| Possible increased incidence and degree of bradycardia and hypotension during sufentanil induction in patients receiving chronic β-blocker therapy1
|| Patients with CAD receiving chronic preoperative β-blocker therapy appear to require lower initial and fewer supplemental doses of sufentanil during CABG surgery than do patients who have not received preoperative β-blocker therapy10
| Calcium-channel blocking agents
|| Increased incidence and degree of bradycardia and hypotension during sufentanil induction in patients receiving chronic calcium-channel blocker therapy1
| CNS depressants (e.g., opiate agonists, general anesthetics, tranquilizers, sedatives, hypnotics)
|| Potentiation of CNS and cardiovascular effects1
|| Use with caution; reduce dosage of at least one of the drugs when used concomitantly1
| Nitrous oxide
|| Possible cardiovascular depression, manifested by bradycardia and decreases in mean arterial pressure and cardiac output, following concomitant administration of nitrous oxide with high doses of sufentanil1
| Neuromuscular blocking agents
|| Possible tachycardia following administration of high doses of pancuronium during anesthesia with sufentanil and oxygen;1 4 38 hypertension and an increase in cardiac index may occur4
Bradycardia and hypotension reported during anesthesia during concomitant administration of neuromuscular blocking agents with sufentanil and oxygen; effects may be increased in patients also receiving calcium-channel blockers or β-blockers;1 bradycardia reported rarely following concomitant administration of sufentanil with succinylcholine1
| To maintain a stable, lower HR and BP during anesthesia, use moderate doses of pancuronium or use a neuromuscular blocking agent with a lesser inhibitory effect on the vagus nerve 1
Following IV administration, the onset of action as determined by time to unconsciousness (i.e., loss of response to voice command) is 1.2–3 minutes.4 10 13 15 16 18
Following epidural administration of 10–15 mcg and 0.125% bupivacaine with epinephrine 1:200,000 during the first stage of labor, the onset of action occurs within 10 minutes.1 88
The mean duration of anesthesia is 40 minutes following initial IV dose of 0.4 mcg/kg and 41–44 minutes following additional doses of 0.1 mcg/kg.20 Following administration of anesthetic doses (about 13–19 mcg/kg total), patient response to verbal command4 13 15 and adequate ventilation4 15 occurs at 0.6–1.8 and 5.6 hours, respectively.
Following IM administration of single doses of 0.15, 0.3, or 0.5 mcg/kg in patients with pain, the approximate duration of detectable analgesia was 2.3, 3.7, and 3.8 hours, respectively.21
Following epidural administration of 10–15 mcg and 0.125% bupivacaine with epinephrine 1:200,000 during the first stage of labor, the duration of action was 1–2 hours.1 88
Distribution into human body tissues and fluids has not been fully characterized;14 however, the drug is highly lipophilic and is rapidly and extensively distributed in animals.4
Not known whether sufentanil crosses the placenta2 or distributes into milk.1 2
Plasma Protein Binding
Approximately 93% bound at plasma pH 7.41 4 6 14 (mainly to albumin; α-, α1-, β-, and γ-globulins; and α1-acid glycoprotein).6 14
Because a large portion of the drug appears to be bound to α1-acid glycoprotein, binding may be affected by disease states in which this protein is altered.4 6 14 24
Binding in plasma is independent of plasma drug concentration within the therapeutic range (i.e., 0.1–10 ng/mL);4 6 however, binding is affected by changes in plasma pH.4 6 14 Increases in plasma pH from 7.4 to 7.8 increase sufentanil binding by about 30%; decreases in plasma pH from 7.4 to 7 decrease binding by about 30%.6
Appears to be metabolized mainly in the liver and small intestine1 2 via N-dealkylation and O-demethylation.4
The O-demethylated metabolite appears to have about 10% of the analgesic activity of the unchanged drug.4
Excreted principally in urine and also in feces via biliary elimination;1 2 60 only 2% of a dose is excreted unchanged in urine and feces.1 2
Triphasic; plasma concentrations decline rapidly secondary to redistribution.1 2 4 5 14 22
In adults with normal renal and hepatic function, the plasma half-life averages 0.72–1.2 minutes in the initial (distribution) phase, 13.7–17 minutes in the second (redistribution) phase, and 140–158 minutes in the terminal (elimination) phase.1 2 4 5 14 22 23
Elimination half-life is longer (434 minutes) in neonates but shorter in infants and children (97 minutes), compared with adults and adolescents.89
15–25°C; protect from light.1
For information on systemic interactions resulting from concomitant use, see Interactions.
Sufentanil citrate is hydrolyzed in acidic solutions.60
| Dextrose 5% in water
| Sodium chloride 0.9%
| Bupivacaine HCl
| Amphotericin B cholesteryl sulfate complex
| Atropine sulfate
| Dexamethasone sodium phosphate
| Diphenhydramine HCl
| Haloperidol lactate
| Hetastarch in lactated electrolyte injection (Hextend)
| Hydroxyzine HCl
| Ketorolac tromethamine
| Metoclopramide HCl
| Midazolam HCl
| Phenobarbital sodium
| Prochlorperazine edisylate
| Remifentanil HCl
| Scopolamine HBr
| Phenytoin sodium
| Thiopental sodium
- A potent analgesic;1 shares the actions of the opiate agonists.1 4 29
- Precise mechanism of action has not been fully elucidated; opiate agonists act at several CNS sites, involving several neurotransmitter systems to produce analgesia.b
- Pain perception is altered in the spinal cord and higher CNS levels (e.g., substantia gelatinosa, spinal trigeminal nucleus, periaqueductal gray, periventricular gray, medullary raphe nuclei, hypothalamus).26 b
- Opiate agonists do not alter the threshold or responsiveness of afferent nerve endings to noxious stimuli, nor peripheral nerve impulse conduction.26
- Opiate agonists act at specific receptor binding sites in the CNS and other tissues; opiate receptors are concentrated in the limbic system, thalamus, striatum, hypothalamus, midbrain, and spinal cord.b
- High affinity and selectivity for the μ-opiate receptor in the CNS; reportedly is more selective and binds more tightly to this receptor than does fentanyl.4 9 12 25 49 52
- Produces dose-related analgesia;1 2 4 at doses up to 8 mcg/kg, the drug has a potent analgesic effect, but higher doses usually produce substantial CNS depression resulting in hypnosis and anesthesia.1 2 4 9 10 11 12 13 19
- Analgesic potency appears to be 5–12 times that of fentanyl on a weight basis.1 12 23 39 40 47 48 50
- Appears to have little effect on histamine release.1 7 53 54 61
- May have a centrally mediated vagal effect.4 60 61
Advice to Patients
- Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as any concomitant illnesses.1
- Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.1
- Importance of informing patients of other important precautionary information.1 (See Cautions.)
Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.
Subject to control under the Federal Controlled Substances Act of 1970 as a schedule II (C-II) drug.1
* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name
|| Dosage Forms
|| Brand Names
|| 50 mcg (of sufentanil) per mL*
|| Sufenta (C-II; preservative-free)
|| Sufentanil Citrate Injection (C-II; preservative-free)
|| Baxter, Hospira
This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.
The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug’s actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.
AHFS Drug Information. © Copyright, 1959-2013, Selected Revisions October 1, 2006. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.
1. Taylor Pharmaceuticals. Sufenta injection prescribing information. Decatur, IL: 1998 Aug.
2. Janssen Pharmaceutica. Product information form for American Hospital Formulary Service on Sufenta. Piscataway, NJ; 1984 Apr 5.
3. Windholz M, ed. The Merck index. 10th ed. Rahway, NJ: Merck & Co., Inc.; 1983:APP-3.
4. Rosow CE. Sufentanil citrate: a new opioid analgesic for use in anesthesia. Pharmacotherapy. 1984; 4:11-9. [IDIS 393492] [PubMed 6230606]
5. Michiels M, Hendriks R, Heykants J. Radioimmunoassay of the new opiate analgesics alfentanil and sufentanil. Preliminary pharmacokinetic profile in man. J Pharm Pharmacol. 1983; 35:86-93. [IDIS 165823] [PubMed 6131992]
6. Meuldermans WEG, Hurkmans RMA, Heykants JJP. Plasma protein binding and distribution of fentanyl, sufentanil, alfentanil and lofentanil in blood. Arch Int Pharmacodyn Ther. 1982; 257:4-19. [PubMed 6214227]
7. Rosow CE, Philbin DM, Keegan CR et al. Hemodynamics and histamine release during induction with sufentanil or fentanyl. Anesthesiology. 1984; 60:489-91. [IDIS 185009] [PubMed 6201089]
8. Hickey PR, Hansen DD. Fentanyl- and sufentanil-oxygen-pancuronium anesthesia for cardiac surgery in infants. Anesth Analg. 1984; 63:117-24. [IDIS 180669] [PubMed 6229197]
9. Rosenbaum JS, Holford NH, Richards ML et al. Discrimination of three types of opioid binding sites in rat brain in vivo. Mol Pharmacol. 1984; 25:242-8. [PubMed 6321946]
10. Stanley TH, de Lange S, Boscoe MJ et al. The influence of chronic preoperative propranolol therapy on cardiovascular dynamics and narcotic requirements during operation in patients with coronary artery disease. Can Anaesth Soc J. 1982; 29:319-24. [IDIS 154371] [PubMed 6213289]
11. de Lange S, Boscoe MJ, Stanley TH et al. Antidiuretic and growth hormone responses during coronary artery surgery with sufentanil-oxygen and alfentanil-oxygen anesthesia in man. Anesth Analg. 1982; 61:434-8. [IDIS 151510] [PubMed 6461279]
12. de Lange S, Stanley TH, Boscoe MJ et al. Catecholamine and cortisol responses to sufentanil-O2 and alfentanil-O2 anaesthesia during coronary artery surgery. Can Anaesth Soc J. 1983; 30:248-54. [IDIS 170873] [PubMed 6242846]
13. de Lange S, Boscoe MJ, Stanley TH et al. Comparison of sufentanil-O2 and fentanyl-O2 for coronary artery surgery. Anesthesiology. 1982; 56:112-8. [IDIS 145245] [PubMed 6119934]
14. Mather LE. Clinical pharmacokinetics of fentanyl and its newer derivatives. Clin Pharmacokinet. 1983; 8:422-46. [IDIS 175719] [PubMed 6226471]
15. Smith NT, Dec-Silver H, Harrison WK et al. A comparison among morphine, fentanyl, and sufentanil anesthesia for open-heart surgery. Induction, emergence, and extubation. Anesthesiology. 1982; 57:A291.
16. Murkin JM, Moldenhauer CC, Griesemer RW et al. Fentanyl vs sufentanil: comparison of hemodynamic and catecholamine responses during coronary artery surgery. In: Proceedings of the Society of Cardiovascular Anesthesiologists 6th Annual Meeting; 1984 May 6-9; Boston. 1984:100-1.
17. Ghoneim MM, Dhanaraj J, Choi WW. Comparison of four opioid analgesics as supplements to nitrous oxide anesthesia. Anesth Analg. 1984; 63:405-12. [IDIS 183551] [PubMed 6230953]
18. Griesemer RW, Moldenhauer CC, Hug CC et al. Sufentanil anesthesia for aortocoronary bypass surgery: 30 mcg/kg vs 15 mcg/kg. Anesthesiology. 1982; 57:A48.
19. Shupak RC, Harp JR, Buchheit WA. High dose sufentanil vs. fentanyl anesthesia in neurosurgery. Anesthesiology. 1982; 57:A350.
20. Kay B, Rolly G. Duration of action of analgesic supplements to anesthesia: a double-blind comparison between morphine, fentanyl and sulfentanil. Acta Anaesthesiol Belg. 1977; 28:25-32. [PubMed 21506]
21. Cathelin M, Vignes R, Malki A et al. Le citrate de sulfentanil administré par voie intra-musculaire: activité analgésique chez l’homme conscient. (French; with English summary.) Anesth Analg Reanim. 1981; 38:21-5.
22. Bovill JG, Sebel PS, Blackburn CL et al. Kinetics of alfentanil and sufentanil: a comparison. Anesthesiology. 1981; 55:A174.
23. Howie MB, Reitz J, Reilley TE et al. Does sufentanil’s shorter half-life have any clinical significance. Anesthesiology. 1983; 59:A146.
24. Holley FO, Ponganis KV, Stanski DR. Effect of cardiopulmonary bypass on the pharmacokinetics of drugs. Clin Pharmacokinet. 1982; 7:234-51. [IDIS 150648] [PubMed 7047043]
25. Leysen JE, Gommeren W, Niemegeers CJ. [3H]Sufentanil, a superior ligand for mu-opiate receptors: binding properties and regional distribution in rat brain and spinal cord. Eur J Pharmacol. 1983; 87:209-25. [PubMed 6132825]
26. Jaffe JH, Martin WR. Opioid analgesics and antagonists. In: Gilman AG, Goodman L, Gilman A, eds. Goodman and Gilman’s the pharmacological basis of therapeutics. 6th ed. New York: Macmillan Publishing Company; 1980:494-534.
27. McClain DA, Hug CC. Intravenous fentanyl kinetics. Clin Pharmacol Ther. 1980; 28:106-14. [IDIS 124822] [PubMed 7389247]
28. Eisele JH, Wright R, Rogge P. Newborn and maternal fentanyl levels at cesarean section. Anesth Analg. 1982; 61:179-80.
29. Hess R, Herz A, Friedel K. Pharmacokinetics of fentanyl in rabbits in view of the importance for limiting the effect. J Pharmacol Exp Ther. 1971; 179:474-84. [PubMed 5136265]
30. Bewley TH, Ghodse AH. Opioid analgesics and narcotic antagonists. In: Dukes MNG, ed. Side effects of drugs. Annual 7. New York: Elsevier/North Holland Inc.; 1983:84.
31. Keykhah MM, Smith DS, Englebach I et al. Effects of naloxone on cerebral blood flow and metabolism. Anesthesiology. 1983; 59:A309.
32. Bovill JG, Sebel PS. Pharmacokinetics of high-dose fentanyl: a study in patients undergoing cardiac surgery. Br J Anaesth. 1980; 52:795-801. [IDIS 123648] [PubMed 7426257]
33. Lunn JK, Stanley TH, Eisele J et al. High dose fentanyl anesthesia for coronary artery surgery: plasma fentanyl concentrations and influence of nitrous oxide on cardiovascular responses. Anesth Analg. 1979; 58:390-5. [IDIS 105685] [PubMed 314761]
34. Flacke JW, Kripke BK, Bloor BC et al. Intraoperative effectiveness of sufentanil, fentanyl, meperidine, or morphine in balanced anesthesia: a double-blind study. Anesth Analg. 1983; 62:259-60.
35. Howie MB, Lingam RP, Lee JJ et al. Sufentanil-oxygen compared with fentanyl-oxygen anesthesia for coronary artery surgery. Anesthesiology. 1982; 57:A292.
36. Fahmy NR. Clinical evaluation of sufentanil-N2O and isoflurane-N2O anesthesia during major orthopedic surgical procedures. In: Advances in anesthesia: a new synthetic narcotic for the 80s; proceedings of a symposium; 1983 Oct 8; Atlanta, GA.
37. Khoury GF, Estafanous FG, Zurick AM et al. Sufentanil/pancuronium versus sufentanil/metocurine anesthesia for coronary artery surgery. Anesthesiology. 1982; 57:A47.
38. Khoury GF, Estafanous FG, Samonte AF et al. Evaluation of sufentanil-O2 versus halothane-N2O/O2 anesthesia for coronary artery surgery. Anesthesiology. 1982; 57:A290.
39. Sebel PS, Bovill JG. Cardiovascular effects of sufentanil anesthesia. Anesth Analg. 1982; 61:115-9. [IDIS 152035] [PubMed 6119930]
40. Moldenhauer CC. Sufentanil anesthesia for cardiac surgery. In: Advances in anesthesia: a new synthetic narcotic for the 80s; proceedings of a symposium; 1983 Oct 8; Atlanta, GA.
41. McKay RD. Short-acting narcotics in neurosurgical anesthesia. In: Advances in anesthesia: a new synthetic narcotic for the 80s; proceedings of a symposium; 1983 Oct 8; Atlanta, GA.
42. Estafanous FG. Use of sufentanil anesthesia with muscle relaxant agents. In: Advances in anesthesia: a new synthetic narcotic for the 80s; proceedings of a symposium; 1983 Oct 8; Atlanta, GA.
43. Smith NT, Dec-Silver H, Sanford TJ Jr et al. EEGs during high-dose fentanyl-, sufentanil-, or morphine-oxygen anesthesia. Anesth Analg. 1984; 63:386-93. [IDIS 183550] [PubMed 6230952]
44. Bovill JG, Sebel PS, Wauquier A et al. Electroencephalographic effects of sufentanil anaesthesia in man. Br J Anaesth. 1982; 54:45-52. [IDIS 146254] [PubMed 6459796]
45. Sebel PS, Bovill JG, Wauquier A. Total narcotic anesthesia with sufentanil. Anesth Analg. 1981; 60:276.
46. McKay RD, Varner PD, Hendricks PL et al. The evaluation of sufentanil-N2O-O2 vs. fentanyl-N2O-O2 anesthesia for craniotomy. Anesth Analg. 1984; 63:250.
47. Kalenda Z, Scheijgrond HW. Anaesthesia with sulfentanil-analgesia in carotid and vertebral arteriography. A comparison with fentanyl. Anaesthesist. 1976; 25:380-3. [PubMed 7967]
48. Van de Walle J, Lauwers P, Adriaensen H. Double blind comparison of fentanyl and sulfentanil in anesthesia. Acta Anaesthesiol Belg. 1976; 27:129-38. [PubMed 801578]
49. Rosenbaum JS, Holford NH, Sadee W. Opiate receptor binding-effect relationship: sufentanil and etorphine produce analgesia at the mu-site with low fractional receptor occupancy. Brain Res. 1984; 291:317-24. [PubMed 6320962]
50. de Castro J, Van de Water A, Wouters L et al. Comparative study of cardiovascular, neurological and metabolic side-effects of eight narcotics in dogs. Pethidine, piritramide, morphine, phenoperidine, fentanyl, R39 209, sufentanil, R34 995. I. Comparative study on the acute toxicity and hemodynamic effects of the narcotics in high and massive doses in curarised and mechanically ventilated dogs. Acta Anaesthesiol Belg. 1979; 30:5-54. [PubMed 382728]
51. Rosow CE, Philbin DM, Moss J et al. Sufentanil vs. fentanyl: I. Suppression of hemodynamic responses. Anesthesiology. 1983; 59:A323. [IDIS 176732] [PubMed 6193743]
52. Stahl KD, Van Bever W, Janssen P et al. Receptor affinity and pharmacological potency of a series of narcotic analgesic, anti-diarrheal and neuroleptic drugs. Eur J Pharmacol. 1977; 46:199-205. [PubMed 22440]
53. Flacke JW, Van Etten A, Flacke WE. Greatest histamine release from meperidine among four narcotics: double-blind study in man. Anesthesiology. 1983; 59:A51.
54. Flacke WE, Van Etten AP, Flacke JW et al. Plasma histamine levels during sufentanil anesthesia for coronary bypass graft surgery. Anesth Analg. 1983; 62:260-1.
55. Bovill JG, Sebel PS, Fiolet JWT et al. The influence of sufentanil on endocrine and metabolic responses to cardiac surgery. Anesth Analg. 1983; 62:391-7. [IDIS 168279] [PubMed 6219596]
56. Young ML, Smith DS, Greenberg J et al. Effects of sufentanil on regional cerebral glucose metabolism in rats. Anesthesiology. 1983; 59:A335.
57. Keykhah MM, Smith DS, C et al. Effects of sufentanil on cerebral blood flow and oxygen consumption. Anesthesiology. 1982; 57:A248.
58. C.dtdson C, Keykhah M, Smith DS et al. Influence of high dose fentanyl on cerebral blood flow and metabolism. Acta Physiol Scand. 1981; 113:271-2.
59. Berthelsen P, Eriksen J, Ahn NC et al. Peripheral circulation during sufentanyl and morphine anesthesia. Acta Anaesthesiol Scand. 1980; 24:241-4. [PubMed 6449821]
60. King W (Janssen Pharmaceutica, Piscataway, NJ): Personal communication; 1984 October 19 and 31.
61. Reviewer’s comments (personal observations); 1984 October.
62. Stanley TH, Philbin DM, Coggins CH. Fentanyl-oxygen anesthesia for coronary artery surgery: cardiovascular and antidiuretic hormone responses. Can Anaesth Soc J. 1979; 26:168-72. [PubMed 380788]
63. Sebel PS, Bovill JG, Schellekens APM et al. Hormonal responses to high-dose fentanyl anaesthesia: a study in patients undergoing cardiac surgery. Br J Anaesth. 1981; 53:941-8. [IDIS 140705] [PubMed 7025877]
64. Howie MB, Smith DF, Harrington K et al. Serum concentrations of sufentanil and fentanyl in the post-operative course in cardiac surgery patients. Anesthesiology. 1984; 61:A131.
65. Mummaneni N, Rao TL, Montoya A. Awareness and recall with high-dose fentanyl-oxygen anesthesia. Anesth Analg. 1980; 59:948-9. [IDIS 129874] [PubMed 7192516]
66. Gosselin RE, Hodge HC, Smith RP et al. Clinical toxicology of commercial products. 5th ed. Baltimore: Williams & Wilkins Co.; 1984: III-284-9.
67. George JM, Reier CE, Lanese RR et al. Morphine anesthesia blocks cortisol and growth hormone response to surgical stress in humans. J Clin Endocrinol Metab. 1974; 38:736-41. [PubMed 4823919]
68. Howie MB, Smith DF, Dasta JF et al. Pharmacokinetic comparison of sufentanil and fentanyl during anesthesia for cardiac surgery. Anesthesiology. 1984; 61:A377.
69. Helgenberg JC. Intraoperative awareness during high-dose fentanyl oxygen anesthesia. Anesthesiology. 1981; 54:341-3. [IDIS 133978] [PubMed 7212338]
70. O’Reilly RA. Anticoagulant, antithrombotic, and thrombolytic drugs. In: Gilman AG, Goodman L, Gilman A, eds. Goodman and Gilman’s the pharmacological basis of therapeutics. 6th ed. New York: Macmillan Publishing Company; 1980:1347-66.
71. Blackburn C. Respiratory arrest after epidural sufentanil. Anaesthesia. 1987; 42:665-6. [PubMed 2956904]
72. Rosman EJ, Capan LM, Turndorf H. Another case of probable seizure after sufentanil. Anesth Analg. 1987; 66:922. [IDIS 233576] [PubMed 2956908]
73. Brian JE Jr, Seifen AB. Tonic-clonic activity after sufentanil. Anesth Analg. 1987; 66:481-3. [IDIS 228986] [PubMed 2953271]
74. Overweg-van Kints J, Blackburn CL, Groen HDB et al. [Apnea following epidural administration of sufentanil.] (In Dutch; with English abstract.) Ned Tijdschr Geneeskd. 1989; 133:988-91.
75. Madej TH, Strunin L. Comparison of epidural fentanyl with sufentanil: analgesia and side effects after a single bolus dose during elective caesarian section. Anaesthesia. 1987; 42:1156-61. [PubMed 2963561]
76. Benlabed M, Ecoffey C, Levron JC et al. Analgesia and ventilatory response to CO2 following epidural sufentanil in children. Anesthesiology. 1987; 67:948-51. [IDIS 237067] [PubMed 2891331]
77. Cohen SE, Tan S, White PF. Sufentanil analgesia following cesarean section: epidural versus intravenous administration. Anesthesiology. 1988; 68:129-34. [IDIS 238213] [PubMed 2892439]
78. Phillips GH. Epidural sufentanil/bupivacaine combinations for analgesia during labor: effect of varying sufentanil doses. Anesthesiology. 1987; 67:835-8. [IDIS 316585] [PubMed 2960254]
79. Rosen MA, Dailey PA, Hughes SC et al. Epidural sufentanil for postoperative analgesia after cesarean section. Anesthesiology. 1988; 68:448-54. [IDIS 310518] [PubMed 2894189]
80. Monk JP, Beresford R, Ward A. Sufentanil: a review of its pharmacological properties and therapeutic use. Drugs. 1988; 36:286-313. [IDIS 246150] [PubMed 2903821]
81. Koren G, Sandler AN, Klein J et al. Relationship between the pharmacokinetics and the analgesic and respiratory pharmacodynamics of epidural sufentanil. Clin Pharmacol Ther. 1989; 46:458-62. [IDIS 259947] [PubMed 2529072]
82. Rosseel PM, van den Broek WG, Boer EC et al. Epidural sufentanil for intra- and postoperative analgesia in thoracic surgery: a comparative study with intravenous sufentanil. Acta Anaesthesiol Scand. 1988; 32:193-8. [PubMed 2896423]
83. Madej TH, Watson NC, Martin BC. Large dose epidural sufentanil: management of postoperative pain with few side effects. Anaesthesia. 1987; 42:1204-6. [PubMed 2963562]
84. Donadoni R, Rolly G. Epidural sufentanil versus intramuscular buprenorphine for postoperative analgesia: a double-blind comparative trial. Anaesthesia. 1987; 42:1171-5. [PubMed 2893560]
85. van der Auwera D, Verborgh C, Camu F. Analgesic and cardiorespiratory effects of epidural sufentanil and morphine in humans. Anesth Analg. 1987; 66:999-1003. [IDIS 235198] [PubMed 2888421]
86. Verborgh C, van der Auwera D, van Droogenbroek E et al. Epidural sufentanil for postsurgical pain relief. Eur J Anaesthesiol. 1986; 3:313-20. [PubMed 2945717]
87. Phillips G. Continuous infusion epidural analgesia in labor: the effect of adding sufentanil to 0.125% bupivacaine. Anesth Analg. 1988; 67:462-5. [IDIS 241360] [PubMed 2966600]
88. Baxter. Sufentanil Citrate Injection prescribing information. Deerfield, IL: 1999 Jan.
89. Food and Drug Administration. Sufenta (sufentanil citrate) injection [August 28, 2001: Akorn]. MedWatch drug labeling changes. Rockville, MD; October 2001. From FDA website ().
a. Trissel LA. Handbook on injectable drugs. 12th ed. Bethesda, MD: American Society of Health-System Pharmacists; 2003:1264-1268.
b. Bailey PL. Clinical pharmacology and applications of opioid agonists. In: Bowdle TA, Horita A, Kharasch ED. The pharmacologic basis of anesthesiology. New York: Churchill Livingstone; 1994:96-103.