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Theochron

Theochron

Generic Name: theophylline (Oral route)

thee-OF-i-lin

OverviewSide EffectsInteractionsMore…

Commonly used brand name(s)

In the U.S.

  • Elixophyllin
  • Norphyl
  • Phyllocontin
  • Quibron-T
  • Quibron-T/SR
  • Theo-24
  • TheoCap
  • Theochron
  • Theo-Dur
  • Theo-Time
  • Truxophyllin
  • Uniphyl

Available Dosage Forms:

  • Elixir
  • Solution
  • Tablet, Extended Release, 12 HR
  • Tablet
  • Capsule, Extended Release, 24 HR
  • Capsule, Extended Release
  • Tablet, Extended Release
  • Capsule, Extended Release, 12 HR
  • Syrup
  • Capsule
  • Tablet, Extended Release, 24 HR
  • Tablet, Enteric Coated

Therapeutic Class: Bronchodilator

Chemical Class: Methylxanthine

Uses For Theochron

Theophylline is used together with other medicines to treat the symptoms of asthma, bronchitis, emphysema, and other lung diseases.

Theophylline belongs to a group of medicines known as bronchodilators. Bronchodilators are medicines that relax the muscles in the bronchial tubes (air passages) of the lungs. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes.

This medicine is available only with your doctor’s prescription.

Before Using Theochron

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of theophylline in children. However, children younger than 1 year of age are more likely to have serious side effects, which may require caution and an adjustment in the dose for patients receiving theophylline.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of theophylline in the elderly. However, elderly patients may be more sensitive to the effects of theophylline than younger adults, and are more likely to have kidney, liver, heart, or lung problems, which may require caution and an adjustment in the dose for patients receiving theophylline.

Pregnancy

Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Bupropion
  • Cimetidine
  • Ciprofloxacin
  • Deferasirox
  • Desogestrel
  • Dienogest
  • Drospirenone
  • Enoxacin
  • Erythromycin
  • Estradiol Cypionate
  • Estradiol Valerate
  • Ethinyl Estradiol
  • Ethynodiol Diacetate
  • Etintidine
  • Etonogestrel
  • Fluvoxamine
  • Halothane
  • Idrocilamide
  • Imipenem
  • Levofloxacin
  • Levonorgestrel
  • Medroxyprogesterone Acetate
  • Mestranol
  • Mexiletine
  • Norelgestromin
  • Norethindrone
  • Norgestimate
  • Norgestrel
  • Pefloxacin
  • Peginterferon Alfa-2a
  • Rofecoxib
  • Thiabendazole
  • Troleandomycin
  • Vemurafenib
  • Zileuton

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Adenosine
  • Adinazolam
  • Alprazolam
  • Aminoglutethimide
  • Amiodarone
  • Azithromycin
  • Bromazepam
  • Brotizolam
  • Cannabis
  • Carbamazepine
  • Chlordiazepoxide
  • Clobazam
  • Clonazepam
  • Clorazepate
  • Diazepam
  • Disulfiram
  • Estazolam
  • Febuxostat
  • Flunitrazepam
  • Flurazepam
  • Fosphenytoin
  • Halazepam
  • Interferon Alfa-2a
  • Ipriflavone
  • Isoproterenol
  • Ketazolam
  • Lorazepam
  • Lormetazepam
  • Medazepam
  • Methotrexate
  • Midazolam
  • Nilutamide
  • Nitrazepam
  • Oxazepam
  • Pancuronium
  • Pentoxifylline
  • Phenobarbital
  • Phenytoin
  • Piperine
  • Prazepam
  • Propafenone
  • Quazepam
  • Rifampin
  • Rifapentine
  • Riluzole
  • Ritonavir
  • Secobarbital
  • St John’s Wort
  • Tacrine
  • Tacrolimus
  • Telithromycin
  • Temazepam
  • Ticlopidine
  • Triazolam
  • Viloxazine
  • Zafirlukast

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Caffeine
  • food

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Congestive heart failure or
  • Cor pulmonale (heart condition) or
  • Fever of 102 degrees F or higher for 24 hours or more or
  • Hypothyroidism (underactive thyroid) or
  • Infection, severe (e.g., sepsis) or
  • Kidney disease in infants younger than 3 months of age or
  • Liver disease (e.g., cirrhosis, hepatitis) or
  • Pulmonary edema (lung condition) or
  • Shock (serious condition with very little blood flow in the body)—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
  • Heart rhythm problems (e.g., arrhythmia) or
  • Seizures, or history of or
  • Stomach ulcer—Use with caution. May make these conditions worse.

Proper Use of theophylline

This section provides information on the proper use of a number of products that contain theophylline. It may not be specific to Theochron. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it and do not take it more often than your doctor ordered. This medicine works best if there is a constant amount in the blood. To keep the blood level constant, take this medicine at the same time each day and do not miss any doses.

After you or your child begin taking theophylline, it is very important that your doctor check the level of the medicine in the blood at regular intervals to decide if the dose needs to be changed. Keep all appointments for testing the blood level.

Take the extended-release capsule or tablet every morning at the same time each day. You may take your second dose 10 to 12 hours after the morning dose and before the evening meal, unless your doctor tells you otherwise.

Swallow the extended-release tablet whole. Do not break, crush, or chew it. You may take the extended-release tablet with or without food.

It is best to take the extended-release capsule one hour before a high-fat meal or without food.

Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • To treat symptoms of asthma, bronchitis, and emphysema:
    • For oral dosage form (elixir or tablets):
      • Adults, teenagers, and children above 1 year of age weighing more than 45 kilograms (kg)—At first, 300 milligrams (mg) per day, divided and given every 6 to 8 hours. Your doctor may adjust your dose as needed. However, the total dose is usually not more than 600 mg per day.
      • Older adults—The dose must be determined by your doctor. However, the total dose is usually not more than 400 milligrams per day, divided and given every 6 to 8 hours.
      • Children and teenagers 1 to 15 years of age weighing less than 45 kilograms (kg)—Dose is based on body weight and must be determined by your doctor. At first, the dose is 12 to 14 milligrams (mg) per kg of body weight per day, divided and given every 4 to 6 hours. Your doctor may adjust your dose as needed. However, the total dose is usually not more than 20 mg per kg of body weight per day or 600 mg per day.
      • Infants younger than 1 year of age—Dose is based on body weight and age and must be determined by your doctor.
    • For oral dosage form (extended-release capsules):
      • Adults, teenagers, and children 12 years of age and older weighing more than 45 kilograms (kg)—At first, 300 to 400 milligrams (mg) as a single dose, usually in the morning, or divided and given two times per day. Your doctor may adjust your dose as needed. However, the total dose is usually not more than 600 mg per day.
      • Older adults—The dose must be determined by your doctor. However, the total dose is usually not more than 400 milligrams per day as a single dose, usually in the morning, or divided and given two times per day.
      • Children and teenagers 12 to 15 years of age weighing less than 45 kilograms (kg)—Dose is based on body weight and must be determined by your doctor. At first, the dose is 12 to 14 milligrams (mg) per kg of body weight per day as a single dose, usually in the morning, or divided and given two times per day. Your doctor may adjust your dose as needed. However, the total dose is usually not more than 20 mg per kg of body weight per day or 600 mg per day.
      • Children younger than 12 years of age—Use and dose must be determined by your doctor.
    • For oral dosage form (extended-release tablets):
      • Adults, teenagers, and children 6 years of age and older weighing more than 45 kilograms (kg)—At first, 300 milligrams (mg) per day, divided and given every 12 hours. Your doctor may adjust your dose as needed. However, the total dose is usually not more than 600 mg per day.
      • Older adults—The dose must be determined by your doctor. However, the total dose is usually not more than 400 milligrams per day, divided and given every 12 hours.
      • Children and teenagers 6 to 15 years of age weighing less than 45 kilograms (kg)—Dose is based on body weight and must be determined by your doctor. At first, the dose is 12 to 14 milligrams (mg) per kg of body weight per day, divided and given every 12 hours. Your doctor may adjust your dose as needed. However, the total dose is usually not more than 20 mg per kg of body weight per day or 600 mg per day.
      • Children younger than 6 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Theochron

It is very important that your doctor check the progress of you or your child at regular visits, especially for the first few weeks after you begin using this medicine. Blood tests may be needed to check for unwanted effects.

A change in your usual behavior or physical well-being may affect the way this medicine works in your body. Tell your doctor if you or your child:

  • Have had a fever of 102 degrees F or higher for at least 24 hours or more.
  • Have started or stopped smoking tobacco or marijuana in the last few weeks.
  • Have started or stopped taking another medicine in the last few weeks.
  • Have changed your diet in the last few weeks.

Stop using this medicine and check with your doctor right away if you or your child have the following symptoms while using this medicine: nausea or vomiting that continues, headaches, trouble with sleeping, seizures, or irregular heartbeats.

Do not stop or change the dose of this medicine without checking first with your doctor.

Before you have any medical tests, tell the medical doctor in charge that you or your child are using this medicine. The results of some tests may be affected by this medicine.

This medicine may add to the central nervous system (CNS) stimulant effects of caffeine-containing foods or beverages such as chocolate, cocoa, tea, coffee, and cola drinks. Avoid eating or drinking large amounts of these foods or beverages while using this medicine. If you have questions about this, check with your doctor.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, and herbal (e.g., St. John’s wort) or vitamin supplements.

Theochron Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

  • Chest pain or discomfort
  • dizziness
  • fainting
  • fast, slow, or irregular heartbeat
  • increase in urine volume
  • lightheadedness
  • persistent vomiting
  • pounding or rapid pulse
  • seizures
  • shakiness

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  • Abdominal or stomach pain
  • blurred vision
  • confusion
  • confusion about identity, place, and time
  • dark-colored urine
  • decrease in frequency of urination
  • decreased urine
  • diarrhea
  • difficulty in passing urine (dribbling)
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • mood changes
  • muscle cramps or spasms
  • muscle pain or stiffness
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • pain or discomfort in the arms, jaw, back, or neck
  • painful urination
  • shakiness in the legs, arms, hands, or feet
  • shortness of breath
  • sweating
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Headache
  • irritability
  • restlessness
  • sleeplessness
  • trouble sleeping
  • unable to sleep

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Theochron side effects (in more detail)

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Theochron

Theochron

Generic Name: theophylline (thee OFF i lin)

Brand Name: Elixophyllin, Theo-24

OverviewSide EffectsInteractionsMore…

What is Theochron (theophylline)?

Theophylline is a bronchodilator. It works by relaxing muscles in the lungs and chest, making the lungs less sensitive to allergens and other causes of bronchospasm.

Theophylline is used to treat symptoms such as wheezing or shortness of breath caused by asthma, bronchitis, emphysema, and other breathing problems

Theophylline may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Theochron (theophylline)?

Do not take theophylline in larger or smaller amounts or for longer than recommended. Theophylline overdose can occur if you accidentally take too much at one time, or if your daily doses are too high. To be sure you are using the correct dose, your blood will need to be tested often.

Do not start or stop smoking without first talking to your doctor. Smoking changes the way your body uses theophylline, and you may need to use a different dose.

Sometimes it is not safe to use certain drugs at the same time. Many drugs can interact with theophylline. Tell your doctor about all other medicines you use. Also tell your doctor if you start or stop using any of your other medications.

Stop using theophylline and call your doctor at once if you have severe or continued vomiting, rapid heartbeats, confusion, tremors, or seizure.

What should I discuss with my healthcare provider before taking Theochron (theophylline)?

You should not use theophylline if you are allergic to it.

To make sure theophylline is safe for you, tell your doctor if you have any of these conditions:

  • a gastric or peptic ulcer;

  • epilepsy or other seizure disorder;
  • heart disease, high blood pressure, a heart rhythm disorder;
  • a high fever (102 degrees or higher);
  • any chronic or recurrent illness;
  • fluid in your lungs;
  • a thyroid disorder;
  • liver disease (especially cirrhosis or hepatitis);
  • kidney disease;
  • serious infection called sepsis;
  • enlarged prostate or urination problems;
  • a history of alcoholism; or
  • if you smoke or have recently quit smoking cigarettes or marijuana.

FDA pregnancy category C. It is not known whether theophylline will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Theophylline can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Do not give this medication to anyone under 18 years old without medical advice.

Serious side effects may be more likely in older adults taking theophylline.

How should I take Theochron (theophylline)?

Follow the directions on your prescription label. Do not take theophylline in larger or smaller amounts or for longer than recommended. Your doctor may occasionally change your dose to make sure you get the best results.

Do not use theophylline to treat an asthma or bronchospasm attack. Use only a fast acting inhalation medication.

Your dose and the number of times you take theophylline daily will depend on the reason you are taking this medication.

Your dosage needs may change if you are ill, or if your doctor changes your brand, strength, or type of theophylline. You will need regular medical tests to be sure you are using the right dose. Do not change your medication dose or schedule without your doctor’s advice.

Take this medicine with a full glass of water.

Follow your doctor’s instructions about whether to take your medication with food or on an empty stomach. Take the medication the same way every time.

Do not crush, chew, break, or open an extended-release tablet or capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.

Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

This medication can affect the results of certain medical tests. Tell any doctor who treats you that you are using theophylline.

Do not start or stop smoking without first talking to your doctor. Smoking changes the way your body uses theophylline, and you may need to use a different dose.

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Seizures caused by a theophylline overdose can cause death or permanent brain damage.

Theophylline overdose can occur if you accidentally take too much at one time. Overdose can also occur slowly over time if your daily doses are too high. To be sure you are using the correct dose, your blood will need to be tested often.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid while taking Theochron (theophylline)?

Avoid eating foods that are high in fat within 1 hour before or after taking theophylline.

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Theochron (theophylline) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using theophylline and call your doctor at once if you have a serious side effect such as:

  • severe or continued vomiting;

  • rapid or uneven heartbeats;
  • seizure (convulsions);
  • confusion, tremors or shaking;
  • nausea and vomiting, severe headache, rapid heart rate;
  • low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling); or
  • high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss).

Less serious side effects may include:

  • stomach pain, diarrhea, upset stomach;

  • headache;
  • sweating;
  • sleep problems (insomnia); or
  • feeling restless, nervous, or irritable;

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Theochron side effects (in more detail)

What other drugs will affect Theochron (theophylline)?

Sometimes it is not safe to use certain drugs at the same time. Some medicines can affect how theophylline works, which could make it less effective or cause side effects. Theophylline could also affect how other medicines work, making them less effective or causing side effects.

Many drugs can interact with theophylline and not all possible interactions are listed in this medication guide. Tell your doctor about all medications you use, start using, or stop using during your treatment with theophylline, especially:

  • cimetidine (Tagamet);

  • fluvoxamine (Luvox);
  • interferon alfa (Intron A, Rebetron, Alferon, Infergen, Pegasys, PegIntron, Sylatron);
  • lithium (Eskalith, Lithobid);
  • ticlopidine (Ticlid);
  • an antibiotic, or medication to treat tuberculosis;
  • heart or blood pressure medication, such as propranolol (Inderal, InnoPran);
  • heart rhythm medication such as mexiletine (Mexitil) or propafenone (Rythmol);
  • medication to treat gout or kidney stones;
  • a sedative such as Valium; or
  • seizure medication.

This list is not complete and many other drugs can interact with theophylline. This includes prescription, over-the-counter, vitamin, and herbal products. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Next Page → Side Effects

More Theochron resources

  • Side Effects
  • Pregnancy Warnings
  • Drug Images
  • Drug Interactions
  • Support Group
  • 0 Reviews - Add your own review/rating
  • Theochron sustained-release tablets MedFacts Consumer Leaflet (Wolters Kluwer)
  • Theochron Advanced Consumer (Micromedex) – Includes Dosage Information
  • Theophylline Prescribing Information (FDA)
  • Theophylline Professional Patient Advice (Wolters Kluwer)
  • Elixophyllin Prescribing Information (FDA)
  • Elixophyllin elixir MedFacts Consumer Leaflet (Wolters Kluwer)
  • Quibron-T MedFacts Consumer Leaflet (Wolters Kluwer)
  • Quibron-T Prescribing Information (FDA)
  • Theo-24 Prescribing Information (FDA)
  • TheoCap Sustained-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)
  • Theolair tablets Prescribing Information (FDA)
  • Theophyllines Monograph (AHFS DI)
  • Uniphyl Prescribing Information (FDA)

Compare Theochron with other medications

  • Apnea of Prematurity
  • Asthma, acute
  • Asthma, Maintenance

Where can I get more information?

  • Your pharmacist can provide more information about theophylline.

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